Sparta Prague have managed to reach the group phase of the elite continental competition or the first time since 2005/06.
They have done so by eliminating the likes of Shamrock Rovers, FCSB, and Malmo FF in the qualifying campaign.
The back-to-back Czech champions have secured domestic dominance in recent years, regaining it after almost a decade-long struggle.
Sparta Prague showed signs of improvements in their recent European adventures as well, managing to reach the last-16 round of the Europa League last season. Liverpool were too strong for them on the occasion.
RB Salzburg have been regular participants of the group stage in recent years. They came fourth in their respective section in the previous term of the competition.
Salzburgās domestic dominance came to an end last season when they came second in the Austrian Bundesliga.
They found the way to the league phase of the Champions League by getting past Twente and Dynamo Kyiv in the qualifying rounds.
Sparta Prague vs Salzburg Prediction
Salzburg suffered their first loss of the season just before the international break, falling 2-3 away at Rapid Vienna more than 15 days ago.
They won just two of the previous five outings across competitions. The poor defensive showing against Rapid Vienna will certainly not boost their confidence ahead of the Champions League opener.