Romelu Lukaku, Scott McTominay and Khvicha Kvaratskhelia start against Monza, as Antonio Conte’s Napoli try to go top of the table.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time.
The Partenopei would be the new Serie A leaders with a victory here, as Torino were beaten 3-2 by Lazio earlier today.
Goalkeeper Alex Meret is out for a month with a muscular strain, so Elia Caprile takes over the gloves.
McTominay got his first goal for Napoli midweek in the 5-0 Coppa Italia win over Palermo and here starts in support of Matteo Politano, Lukaku and Kvaratskhelia in a 4-3-3 formation.
Monza have struggled under coach Alessandro Nesta, but came close to beating Inter until conceding a late goal for 1-1 and beat Brescia 3-1 in the Coppa Italia on Thursday.
Alessio Cragno, Patrick Ciurria, Samuele Birindelli, Roberto Gagliardini and Samuele Vignato are all carrying knocks.
Milan Djuric is again the choice of centre-forward, with Daniel Maldini and Matteo Pessina.
Napoli-Monza line-ups
Napoli: Caprile; Di Lorenzo, Rrahmani, Buongiorno, Olivera; Anguissa, Lobotka, McTominay; Politano, Lukaku, Kvaratskhelia.
Monza: Turati; Izzo, Pablo Mari, A Carboni; Pereira, Bianco, Bondo, Kyriakopoulos; Maldini, Pessina; Djuric.
